This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...
For human tissues, prior experimental manipulations are impractical, and genomic alterations are employed. Somatic mutations mark subclones and their fates can be reconstructed with DNA sequencing ...
In PSC, bile duct cells display degenerative and atrophic features, contributing to disease progression. Research indicates that specific bile duct cell subsets can proliferate and differentiate into ...
Researchers have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more ...