A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

【导读】肿瘤微环境（TME）是由复杂的细胞间通讯所调控的动态系统。具体来说，TME中的巨噬细胞在驱动肿瘤进展方面发挥着关键作用。外泌体是肿瘤细胞与TME之间通讯的关键介质。然而，在结直肠癌（CRC）进展过程中，外泌体介导的肿瘤细胞与巨噬细胞之间的通讯 ...

Study identifies pro-inflammatory macrophage subtype with distinct genetic features in inflamed joints of RA patients.

由于研究人员无法预测哪些患者会发展成为严重的侵蚀性疾病，以及哪些患者会对疗法产生反应，所以他们会普遍采用试错的方法，在患者接受正确治疗之前往往会导致患者出现不可逆转的关节损伤。近日，一篇发表在国际杂志 Science Advances 上题为 ...

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an ...

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an ...

A new study proposes a better understanding of the site of inflammation in RA which will allow for the development of new treatment strategies or predictive biomarkers which could support the ...

Researchers demonstrated for the first time, the presence of a dominant macrophage subtype (CD40-expressing CD206+CD163+) in the inflamed RA synovium, which importantly was associated with disease ...

Several subsets of macrophage have been found to closely associate with metastasis-initiating cells in the tumor microenvironment. A team of researchers at the Johns Hopkins Kimmel Cancer Center (MD, ...

Strategies that target chronic inflammation are of potential therapeutic benefit for patients with Achilles tendon disease. More recent studies have identified immune-competent cells including ...