In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, ...

A recent study published in Life Metabolism reports that high temperature can ameliorate insulin resistance by promoting ceramide catabolism in skeletal muscle tissue (SMT) of obese mice.

More information: Qingzhang Zhu et al, PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels, Nature Metabolism (2024). DOI: 10.1038/s42255-024-01078-9 ...