The complement system has more than 50 soluble and membrane-bound proteins. In innate and adaptive immunity, complement is essential for eliminating foreign pathogens and apoptotic cells.
Alzheimer's disease is characterized by the presence of neurofibrillary tangles and amyloid-β (Aβ) plaques, which co-localize with various inflammation-related proteins and activated microglia.
The complement community is shifting gear, with more companies than ever targeting alternative complement proteins for their therapies ... which inhibitor will be the next to harness the complement ...