For 20 years, neuroscientists — including myself — have used cutting-edge microscopy technology in living animals to observe microscopic structures called dendritic spines constantly budding out, ...
DEPTAC. Based on PROTACs, or protein-targeting chimeras, D20, a dephosphorylation-targeting chimera, delivers PP1 to tau. The C-terminal tail (gray) helps the construct enter cells. [Courtesy of Xiao ...