US-based biopharmaceutical company CASI Pharmaceuticals has administered the first dose of FOLOTYN (pralatrexate) to a patient with PTCL in China. Pralatrexate is a dihydrofolate reductase ...

Altered target enzymes (increased dihydrofolate reductase activity or expression, kinetically altered dihydrofolate reductase, increased 5-aminoimidazole-4-carboxamide ribonucleotide ...

Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Dilute (see full labeling ...