After exposure to trans-retinoic acid, these cells can develop into two distinct forms of extra-embryonic endoderm. To date, differential library screening has been the best tool available to ...

We are interested in how cells become specialized, and how they collaborate at the population level to collectively build organs. Our focus is on the endoderm, the progenitor tissue that gives rise to ...

To treat his impaired islet cell function, the research team generated functional islet-like clusters, called “E-islets,” from the patient’s own endoderm stem cells derived from blood cells.