This cascade leads to cellular dysfunction and death. The unique features of ferroptosis—iron dependency, ROS generation, and ...

The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ...

DILI is broadly categorized into intrinsic and idiosyncratic types. Intrinsic hepatotoxins, such as APAP, cause ...

Understanding the relationship between ferroptosis, reactive oxygen species (ROS), and lipid metabolism is crucial. Nanomaterials offer precision and efficiency in delivering therapeutic agents to ...

Overall, this fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. The evidence supporting the ...