We have previously reported that cultures of C. albicans activated the amebocyte lysate clotting cascade of the Japanese horseshoe crab Tachypleus tridentatus. In order to isolate the active agent ...

interacts with coagulation factor VIIa to initiate the plasma coagulation cascade. The TF and factor VIIa complex triggers the activation of other clotting factors, which leads to the formation of ...

This is because calcium repletion reactivates the clotting cascade and calcium infused into the return line increases the risk of clotting within the catheter and the loss of the circuit due to ...