They described the membrane-like barrier as a "saclike structure surrounded by a membrane and containing acid ... suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar ...

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

Recent studies suggest that these granules can "hitch a ride" from lysosome-related vesicles, membrane-bound structures in ...

They identified two distinct modes of endosomal fusion: homotypic fusion, where two endosomes fuse rapidly to form a single ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

APOE genotype was shown to influence vesicle trafficking pathways in aged APOE Targeted Replacement mice, with APOE2 and APOE4 appearing to have opposite effects when compared with APOE3. More ...

Thomas Fai and Avital Rodal Fai is generating image processing tools to extract how the spatial and biochemical organization of the presynaptic periactive zone relates to vesicle release probability, ...

None of the mail has been deemed hazardous so far but it has caused evacuations. The FBI and Postal Service are investigating suspicious mail containing a white powder substance that was sent to ...

Those with a peanut allergy have been told to avoid eating food containing mustard over fears they have been contaminated. Rebecca Sudworth, the Food Standards Agency's (FSA) director of food ...

The sunken vessel, lying on the seabed at a depth of some 50 meters (164 feet), is thought to have watertight safes containing two super-encrypted hard drives that hold highly classified ...