The chronic and progressive inflammatory disease bronchiectasis is characterised by permanent bronchi dilation and by ...

Immunohistochemical localization of oxPL contrast agent within atherosclerotic plaque confirmed selective accumulation in macrophages. Phagocytosis of oxPL in human macrophages involves α v β 3 ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

More importantly, OASCLR enhanced the phagocytosis ability of macrophages at second pneumonia by down-regulating the expression of SP-D.

Dr Yang Liu shares his insights into the preclinical studies behind the development of drug candidates targeting the ...

These cells deal with microbes and repair tissue damage. Two main sub-types of immune cells are T cells and macrophages. T cells are designed to recognise the molecular signatures of particular ...

When foreign particles and pathogens pass your airways' first line of defense (mucus and cilia), specialized immune cells in the alveoli called alveolar macrophages help detox your lungs. During a ...

Inflammation of the arteries is a primary precursor and driver of cardiovascular disease—the No. 1 killer of people in the ...

The $4.9 billion acquisition of Forty Seven by Gilead is an example of the explosive excitement and investment into macrophage-directed therapies, utilizing CD47 checkpoint blockades ...

Studies have shown that the factors that promote the healing of diabetic foot ulcer are related to inhibiting apoptosis, promoting fibrocyte proliferation, promoting angiogenesis, accelerating ...

– Subcutaneously administered AK006 showed approximately 77% bioavailability and prolonged receptor occupancy on mast cells – – Subcutaneous AK006 was well-tolerated with a favorable safety profile – ...