Microglia are the brain's resident immune cells. Their job is to patrol the brain's blood vessels looking for invading ...

Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. For example, it is well known that the activation of the ...

Scientists study the functions of microglia by transcriptomics. This method provides dynamic information about genes that are ...

In conclusion, these findings shed light on the cellular mechanisms of microglial activation in response to hyperosmotic stress, highlighting the roles of NFAT5 and NCX, and supporting the ...

Genetically-modified hematopoietic cells enter the CNS and differentiate into microglia after bone-marrow transplantation. Up to a quarter of the regional microglial population is donor-derived by ...

Interestingly, this process seemed to operate independently of NFAT5, suggesting multiple activation pathways are involved in ...

Researchers have discovered that two genetic variants, APOE4 and TREM2 R47H, together cause a harmful inflammatory response ...

Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using ...

In a previous study, Professor Yoshihisa Sugimura from the Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University found that microglia, resident immune ...

Liver X receptor beta (LXRβ) shows potential in reducing depression and anxiety by improving neurogenesis, reducing ...

Neural stem cells (NSCs) play a crucial role in the progress of ischemic stroke. Research on zebrafish embryonic demonstrates an association between Strawberry Notch 1 (Sbno1) and central nervous ...