Given compelling links between RXR activation and increased myelin repair, the collaborating scientists employed IRX4204 to investigate the impact of RXR agonism on functional recovery in mice ...

How does our nervous system operate so quickly and efficiently? The answer lies in a membranous structure called myelin. Aa Aa Aa All our activities — eating, walking, talking — are controlled ...

Conditional knock-out mice in which Myrf is knocked out in the OL lineage cells completely fail to develop CNS myelin and exhibit severe neurological symptoms, eventually prematurely dying. Recently, ...

We have recently discovered that mechanical forces generated by the extracellular matrix and other cells are also essential for correct myelination, and we are actively pursuing the molecular ...

Myelin also repairs itself faster in mice models than in humans, which is why the researchers genetically modified the mice ...

The research is published in the journal Science. Most nerve fibers in vertebrates are encased in sheaths made largely of ...

Toluidine blue staining. Myelin is stained in blue. The nerve tract is filled with ring-shaped structures, indicating a transverse section of myelinated nerve fibers. (D) Electron microscopy of a ...

Emma Phipps, 44, from Wansford near Peterborough, joined the University of Cambridge trial which hopes to repair myelin - a protective layer surrounding nerve fibres which get damaged due to MS.