and interestingly the induction of p53 in the two cell types happened at different times. The stem cells that enter cell-cycle arrest are an obvious problem for radiation therapy. Therefore the ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Wild-type p53 is often engaged in response to cellular damage, where it acts to regulate genes that promote cell-cycle arrest, apoptosis, senescence, differentiation, and autophagy (Figure 1). In ...

Organ-on-chips are ... Stem Cell Transplants Close Macular Holes in Monkeys Oct. 3, 2024 — Human stem cell transplants successfully repaired macular holes in a monkey model, researchers report.

Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant ... PMID: 39048830 Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, ...

It “opens up a complete new avenue [to rescue] this magnificent species and icon of conservation,” and may suggest strategies for generating stem cells for other vulnerable and endangered species.

Studies over the past decade have suggested that treatment via pluripotent stem cells—a type of unspecialized cell that can develop into other types of cells—could lead to a cure, per the ...

p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged cells before they can become malignant. However, in more than 50% of ...

We're all very complex organisms, made up of lots of different types of cells carrying out different jobs in our bodies; such as nerve cells, blood cells, fat cells and muscle cells. So, where do ...

And they argue that scientists can achieve the same results using adult stem cells— immature cells found in bone marrow and other organs in adult human beings, as well as in umbilical cords ...

If cells are removed from the embryo they will differentiate into any cell type. These are called embryonic stem cells. Some stem cells remain in the bodies of adults as adult stem cells.

Opinions expressed by Forbes Contributors are their own. William A. Haseltine, Ph.D., covers genomics and regenerative medicine This story is part of a series on the current progression in ...