an siRNA-based inhibitor of RNA-binding protein LIN28B. TransCode also has three cancer agnostic programs—TTX-RIGA, an RNA–based agonist of the retinoic acid-inducible gene I (RIG-I)–driven ...

“So if you think of a big RNA molecule you [could] have two different chaperones binding at ... and using them as inhibitors. “Anything that you can do with a protein antibody interaction ...

We demonstrated that the RNA binding protein hnRNPM reprograms alternative splicing including CD44 and promotes ... Therapeutic resistance of promising anti-tumor drugs, such as the anti-HER2 antibody ...

Recent research has established that Insulin-like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) RNA-binding protein is involved in leukemia development, particularly in the KMT2A-translocated ...

In addition, research is focused on protein-RNA complexes mediating the piRNA pathway (with Julius Brennecke, IMBA-Austria), on identification and characterization of small molecule inhibitors ...

The biochemical functions of proteins invariably involve interactions with ligands of some type, which act as enzyme substrates or inhibitors ... of the ligand-binding regions is also extremely ...