It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

have shed new light on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis (UC) – an ...

As a result, the degenerated cell eventually multiplies and a tumor can grow. In about one out of two tumors, such a mutation of the p53 protein can be detected. Cancer researchers are therefore ...

Cellular senescence is a stress-response program (Figure 1) that is potentially tumor suppressive. We previously showed that senescence arises through chromatin remodeling that silences proliferative ...