A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail.

A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail.

Wound healing serves an important function in biology ... It is a potent inhibitor of normal epithelial cell proliferation and possesses tumor suppressing activity. The majority of human tumors are of ...

Understanding the mechanisms that drive the transition from an inflammatory to a proliferative phase during wound healing can aid in developing novel strategies for enhanced tissue repair.

Before choosing a dressing, however, the clinician must remember the three phases of wound healing: the inflammatory phase, the proliferative phase, and the remodeling phase. The inflammatory ...

Additionally, they demonstrated that this ECM glycoprotein increases EpSC proliferation and enhances wound healing, suggesting that TGFBI regulates EpSC function. Fibroblasts respond to tissue injury ...

now report a role for cell death in wound healing and tissue regeneration ... signal to stem and progenitor cells to stimulate their proliferation and initiate tissue repair.

Disruptions during wound healing phases (inflammation, proliferation, and remodeling) can result in scar formation. Higher levels of inflammatory markers (TGF-β1, TGF- β2, VEGF) and type 1 ...

and induces cell proliferation and migration. Self-powered ES devices have been developed, which significantly expedite wound ...