The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

The orderly arrangement of cells in tissues depends on complex signaling between cells. Learn how cellular junctions play important roles in cell adhesion and communication.

Vedolizumab (Entyvio) and infliximab (Remicade) led to mostly similar 1-year outcomes in patients with ulcerative colitis ...

Janssen opted not to continue with the first two integrin targets at the end of 2021, due to "a lack of target validation in the specific disease of Janssen's interest," and has now dropped the ...

A significant advance in breast cancer research has uncovered a key mechanism driving cancer invasion and drug resistance. A ...

A significant breakthrough in breast cancer research has uncovered a key mechanism driving cancer invasion and drug ...

A significant breakthrough in breast cancer research has uncovered a key mechanism driving cancer invasion and drug ...

These proteins, HER2 and aVb6 integrin, are already known to independently predict cancer outcomes, but have now been found to work together through a newly discovered 'crosstalk' mechanism that ...

Bexotegrast is a small molecule commercialized by Pliant Therapeutics, with a leading Phase III program in Idiopathic Pulmonary Fibrosis.

“CRB-601 offers an intriguing upstream approach to modulating TGFβ signaling and this dose escalation study could yield valuable insights along with the potential to see the immune system being ...