The design of this lentiviral vector raises unique safety risks, because expression of the therapeutic transgene is driven by a potent murine γ-retroviral enhancer–promoter that can efficiently ...
Autologous HSCs were transduced with CD68-LV-ET3 — a lentiviral vector including a new F8 transgene (ET3) with a myeloid-directed CD68 promoter — either without transduction enhancer (group 1 ...
Current lentiviral vector systems (the third generation) generate virus particles using four plasmids and a producer cell line. The rationale behind four plasmids is to enhance safety, as ...
Download this application note from Thermo Fisher Scientific to learn how scientists have used their lentiviral production system, single-use bioreactors, and clarification products to generate ...