Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic ...

In a series of in vivo and in vitro studies, the investigators established that astrocyte immune memory is driven by an ...

In their new study, Jones and his colleagues identified two routes for acetyl-CoA production—a main route called ACLY and a backup route called ACSS2. Cells prefer ACLY but, in the event of ...

In a sort of domino effect, the original nutrient was ultimately determining T cell fate—(1) the metabolic enzyme (ACSS2 or ACLY) determined the nutrient used, (2) the metabolic enzyme determined the ...