Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic ...

The novel link between nutrition and cell identity offers a new explanation for exhausted T cell identity and in turn, offers ...

This was supplemented by the role of key enzymes responsible for acetyl-CoA formation within the cytosol and their expression levels in different diseases. We offered a progress report for the small ...

Scientists have discovered that our specialized immune cells, called T cells, are what they eat -- their switch from functional to 'exhausted' depends on the switch from metabolizing acetate to ...

The decision between scrambled eggs or an apple for breakfast probably won't make or break your day. However, for your cells, ...

FLEMING 1 noted that the growth of B. coli and a number of other bacteria belonging to the colityphoid group was not inhibited by penicillin. This observation has been confirmed. Further work has ...

In a sort of domino effect, the original nutrient was ultimately determining T cell fate—(1) the metabolic enzyme (ACSS2 or ACLY) determined the nutrient used, (2) the metabolic enzyme determined the ...

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How does your body speed up these important reactions? The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a ...