Among them, UNC45 plays a critical role in muscle health by ensuring the proper function of myosin ... into how disruptions in myosin quality control can lead to serious muscle disorders. Their ...

Stress fibres are contractile bundles of actin filaments and myosin, which can attach to focal adhesions and function in cell adhesion, migration and mechanotransduction. Different types of stress ...

The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.

Myosins use the energy stored in a chemical called ATP to move along filaments made from another protein called actin and produce force. The same part of the myosin protein that binds to and uses ATP ...