The study is, however, incomplete due to the lack of several controls and its focus on overexpression and mutants lacking key domains. Activation of the Wnt/β-catenin pathway crucially depends on ...

With General Election count concluded, RTÉ's Political Correspondent Paul Cunningham examines the five steps which will lead to the formation of the next coalition government. 1) Parliamentary ...

Another, Pathway, has just raised a $10 million seed round to build live AI systems that, claims the company, think and learn in real time as humans do. The round was led by TQ Ventures ...

METTL3-mediated m6A methylation occurs at the stop codon of ZMYM1 mRNA and enhances ZMYM1 expression via a m6A-HuR-dependent pathway. ZMYM1 binds to E-cadherin by recruiting the CRS site of the ...

ATX968 was identified as a potent and selective inhibitor of DHX9 helicase activity. Chemical inhibition of DHX9 enzymatic activity elicited similar selective effects on cell proliferation as seen ...

Gpr54 deletion also raises the number of CD34+ and Lgr5+ HFSCs. The Gpr54 inhibitor, kisspeptin234, promotes hair shaft growth in cultured mouse hair follicles and boosts synchronized hair ...

Researchers from Ohio State University hypothesized that 12,13-diHOME may act by inhibiting the proarrhythmic molecule Ca2+/calmodulin-dependent kinase II (CaMKII). Linoleic acid metabolite reduces ...

The State Key Laboratory of Chemical Oncogenomics, Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, P. R. China The ...

Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States ...