Stage 1 melanoma has two distinct categories: 1A: The tumor is less than 1 millimeter (mm) thick and may be with or without ulceration. 1B: The tumor is between 1 mm to 2 mm thick with no ulceration.

Lufepirsen is under clinical development by Amber Ophthalmics and currently in Phase II for Persistent Corneal Epithelial Defects.