The drug candidate is administered orally as a capsule. The drug candidate targets glucosylceramide synthase (GCS). It is a new molecular entity (NME). It was under development for Parkinson's disease ...

Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States ...

The low-density lipoprotein receptor (LDLR) is the primary mechanism for uptake of cholesterol-carrying particles into cells. The region of the LDLR implicated in receptor recycling and ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

This study investigates the molecular mechanisms underlying chronic pain-related memory impairment by focusing on S1P/S1PR1 signaling in the dentate gyrus (DG) of the hippocampus. Through behavioral ...

Department of Analytical Chemistry, University of Pardubice, Faculty of Chemical Technology, Studentská 573, Pardubice 53210, Czech Republic ...