Researchers have identified that the status of the T-cell Golgi apparatus is a key indicator of performance in cancer immunotherapy approaches. A group of researchers working at the Medical University ...

The Golgi apparatus modifies, sorts, and packages proteins to be sent to their final destinations, whether within or outside the cell. It is a core function but little studied in cancer immunology ...

This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the regulatory basis. Design Hepatic PHLDA3 expression was ...

Clin Lipidology. 2014;9(1):101-118. TAUSSIG: a multicenter, open-label study to assess the long-term safety, tolerability, and efficacy of AMG145 on LDL-C in subjects with severe familial ...

1 Shandong University of Traditional Chinese Medicine, Jinan, China 2 Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, China Background: The etiopathogenesis of hepatic ...

zju.edu.cn, zyyyych{at}zju.edu.cn Objective Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading to non-alcoholic fatty liver disease (NAFLD). This study aimed to ...

Acute pancreatitis (AP) is an inflammatory disease of the pancreas and a complex process involving multiple factors, with mitochondrial damage playing a crucial role. Mitochondrial dysfunction is now ...

This protein is synthesized in hepatocytes and secreted as the holoprotein with six atoms of copper incorporated during transit through the late secretory pathway. Although copper has no effect on ...