Production begins when tissue factor in the extrinsic coagulation pathway is exposed ... Factor IXa then moves into the intrinsic pathway and combines with factor VIIIa and calcium to form a ...

See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the final product of ...

Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, ...