We found that ADGRA3 facilitates the biogenesis of beige adipocytes through the Gs-PKA-CREB axis. Moreover, hesperetin was identified as a potential agonist of ADGRA3, capable of inducing adipocyte ...

In INSIE cells and fibroblasts, S1P affects cAMP levels and the MAPK pathway, influencing PKA activity and inflammatory responses mediated by MKP-3, ERK1/2, NF-κB, TNF-α, and IL-6. These interactions ...