However, the role of these cells in ECM protein degradation has not been fully elucidated. Aims: To determine: (i) whether PSCs secrete matrix metalloproteinases (MMPs) and tissue inhibitors of ...

An enlarging family of matrix-metalloproteinases has been identified that are calcium-dependent enzymes which specifically degrade collagens and noncollagenous substrates (see [37] for review).

Researchers have uncovered a significant mechanism involved in liver fibrosis. Their findings have been published in the ...

Snakes, known for their rapid evolution, are among the most dangerous animals due to their venomous bites, causing numerous ...

AbbVie and Nimble Therapeutics have announced an acquisition deal in which AbbVie will gain ownership of the company’s ...

The agents of destruction include inflammatory cells, cytokines, and protein-degrading enzymes known as matrix metalloproteinases (MMPs). The vicious cycle begins when inflammatory cells ...

Sneha Khedkar is an Assistant Editor at The Scientist. She has a Master's degree in biochemistry and has written for Scientific American, New Scientist, and Knowable Magazine, among others. View full ...

Pearls, symbols of elegance and beauty, are formed within oysters not from grains of sand, but as a defense mechanism against ...

Coronary aneurysm, a dilated segment of the coronary artery, is a rare condition with a prevalence ranging from 0.02% to 0.2%. According to the current literature, reports of large aneurysms in the ...

In inflamed airways, reactive oxygen species (ROS) activate signaling pathways, like mitogen-activated protein kinases (MAPKs), which augment the inflammatory response, causing cellular influx and ...