In a potential advance for melanoma patients, researchers at ChristianaCare’s Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of ...

The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies. Non-small cell lung cancer (NSCLC) is the most common subtype of lung ...

They recently discovered that disabling a lung cancer gene called NRF2 using CRISPR gene editing allows chemotherapy to work better to target cancer cells. The Gene Editing Institute, working with its ...

NRF2, nuclear factor erythroid 2-related ... ccRCC is often associated with the deletion or mutation of the VHL gene, enhancement of glucose and lipid metabolism, and heterogeneity of the tumor ...

The Nrf2 pathway stimulates the expression of genes linked to NADH regeneration and redox detoxification ... More efficient and potentially disease-modifying treatments that target ferroptosis for ...

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It also highlights their use for the search for target genes of the tumour suppressor p53. Over the past two decades, several methods have been developed to allow comparative studies of gene ...

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