Like FLO, intra-paw injection of HC-HA/PTX3 dose-dependently (10-20 μg) induced heat antinociception in naïve WT mice and attenuated heat hypersensitivity developed in the hindpaw after ...
Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Centre – UnIC@RISE, Faculty of Medicine of the University of Porto, Portugal (J.P.F.). Heart Failure Clinic, Internal Medicine ...
Morphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses ...