喜树碱-鸡卵清白蛋白偶联物（Camptothecin Ovalbumin Conjugate，简称CPT-OVA）是将喜树碱（Camptothecin，CPT）与鸡卵清白蛋白（Ovalbumin，OVA）通过化学方法偶联得到的复合物。以下是对其的详细介绍： 一、组成成分 喜树碱：喜树碱是一种细胞毒性喹啉类生物碱，化学名为4 ...

Key Laboratory of Radiopharmaceuticals, Ministry of Education; College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

Last year, it also revived a collaboration with ImmunoGen, more than a decade after backing away from a relationship, to claim an interest in its camptothecin payload technology. That deal ...

Chemists are able to synthesize, and deduce the structure of, ever more complex molecules produced by nature, but what does the future hold for this venerable field, and what are the new challenges?

Zai Lab’s investigational next-generation ADC ZL-1310 is composed of a humanized anti-DLL3 monoclonal antibody linked to a novel camptothecin derivative (a topoisomerase 1 inhibitor) as its payload.

1 Department of Pharmacology, School of Basic Medicine, Qingdao University, Qingdao, China 2 Department of Clinical Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China ...

Chemoproteomics has proven to be an indispensable tool in elucidating the biosynthetic pathways of complex natural products like steviol glycosides, chalcomoracin, and camptothecin. The ability to ...

Dr S F Moss, Division of Gastroenterology, Department of Medicine, St Luke’s-Roosevelt Hospital Centre, S&R 12, 1111 Amsterdam Ave, New York, NY 10025, USA. BACKGROUND Altered expression of lamins A/C ...