Intra-amniotic infection (IAI), or chorioamnionitis, complicates up to 10% of all pregnancies and up to 2% of labors at term. There is a significant risk of complications for the mother and the ...

Available guidelines delineate chorioamnionitis as a contraindication for antenatal steroids. However, observational evidence suggests antenatal steroids to be safe and effective in chorioamnionitis.

Conversely, histologic chorioamnionitis can be present without clinical symptoms. In one study, subclinical infection was present two to three times more commonly than clinical infection.