This manuscript describes a fundamental investigation of the functioning of Cas9 and in particular on how variant xCas9 expands DNA targeting ability by an increase-flexibility mechanism. The authors ...

Human α-lactalbumin (α-LA) is a four disulfide-bonded protein that adopts partially structured conformations under a variety of mildly denaturing conditions. At low pH, the protein is denatured ...

Department of Chemical Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, U.K. Institute of Chemical Biology, Molecular Sciences Research Hub, Imperial College London, ...

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China State ...