This study investigated hepatocyte-abundant miRNAs dysregulated by ALD, its impact on hepatocyte injury and the underlying basis. Design Alcoholic hepatitis (AH) human and animal liver samples and ...

Lentiviral delivery of PHLDA3 shRNA to mice abrogated p-Akt inhibition in the liver by Tm, attenuating hepatocyte injury. Conclusions ER stress in hepatocytes induces PHLDA3 via IRE1–Xbp1s pathway, ...

A recent review published in eGastroenterology discusses recent advancements in understanding alcohol-associated liver ...

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal endothelium, Kupffer cells, hepatocytes, platelets ...

In everyday life, when things turn out the opposite of what you expect, it's usually a cause for frustration. In science, ...

AHCC demonstrates potential in preventing liver fibrosis progression by inhibiting HSC activation and regulating key pathways ...

as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...

Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage gene editing company utilizing its novel proprietary ARCUS® ...