Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

The Lysosome This small particle acts as the digestive tract of the living cell. Its enzymes dissolve the substances ingested by the cell and under certain circumstances can dissolve the cell itself ...

Furthermore, they found that downregulation of BAG3, a protein involved in protein clearance through the autophagy-lysosome ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

与传统药物递送相比，靶向递送在临床药物治疗中具有更低的毒性和更大的治疗窗口。在过去的几十年里，研究者们更加重视将药物特异性递送到器官、组织或特定细胞中，尽管这些策略提高了药物的靶组织蓄积和靶细胞内化，但不受控制的胞内过程会导致药物被胞质稀释、胞内靶点 ...