This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

Extracting exons from pre-mRNA and splicing them together to create mRNA requires, first and foremost, a mechanism for distinguishing exons and introns. Intron recognition always takes place ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Root-knot nematodes pose a significant threat to agriculture, infecting a wide range of crops and causing billions of dollars ...

A new study has uncovered the complex genetic interaction between root-knot nematodes and tomato plants, revealing how these ...

These patients are thought to carry deep intronic variants, structural variants or splicing alterations not detected through multiplex ligation ... Results We identified an alteration in the mRNA ...

The German gene therapy developer will test VG801 in patients with Stargardt disease and other retinal dystrophies linked with ABCA4 mutations.

Insights into protein synthesis processes in prokaryotes and eukaryotes are crucial for advancements in genetics, ...

When the team used the most promising of these LNPs to deliver mRNA molecules coding for VEGF to pregnant mice with pre-eclampsia, the mice’s blood pressure returned to normal for the ...

But, by laying this groundwork, Swingle's work has not only identified an avenue for curing pre-eclampsia, it also opens doors for research on LNP-mRNA therapeutics addressing other reproductive ...