Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic ...

She is also an avid reader and an amateur photographer. Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.

Scientists have discovered that our specialized immune cells, called T cells, are what they eat -- their switch from functional to 'exhausted' depends on the switch from metabolizing acetate to ...

In a sort of domino effect, the original nutrient was ultimately determining T cell fate—(1) the metabolic enzyme (ACSS2 or ACLY) determined the nutrient used, (2) the metabolic enzyme determined the ...

The novel link between nutrition and cell identity offers a new explanation for exhausted T cell identity and in turn, offers ...

The decision between scrambled eggs or an apple for breakfast probably won't make or break your day. However, for your cells, ...

In a sort of domino effect, the original nutrient was ultimately determining T cell fate—(1) the metabolic enzyme (ACSS2 or ACLY) determined the nutrient used, (2) the metabolic enzyme determined the ...

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However, CMA is also a negative regulator of anabolism, and it degrades enzymes required for glycolysis ... several proteins that negatively regulate vertebrate lifespan, such as MYC, NLRP3, ACLY, and ...

The activation of PPARδ can promote the expression of genes related to fatty acid oxidation, such as ATP citrate lyase (ACLY) and stearoyl-CoA desaturase 1 (SCD1). It also activates the enzyme ...