Trajkovic et al. now report that exosome biogenesis requires the sphingolipid ceramide, whereas the ESCRT (endosomal sorting complex required for transport) machinery is only needed for ILVs that ...

In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, ...

A recent study published in Life Metabolism reports that high temperature can ameliorate insulin resistance by promoting ceramide catabolism in skeletal muscle tissue (SMT) of obese mice.

More information: Qingzhang Zhu et al, PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels, Nature Metabolism (2024). DOI: 10.1038/s42255-024-01078-9 ...