Caption This image depicts a single memory engram cell in the hippocampal dentate gyrus region of a mouse model of early Alzheimer's disease. To optically manipulate specific connections to these ...

The hippocampus is a forebrain structure located within the medial temporal lobe that consists of the subiculum, CA1, CA2, CA3 and dentate gyrus regions. The hippocampal formation also includes ...

(Right Panel) We observed significant increases in functional connectivity between the targeted hippocampal region and several cortical regions including the left precuneus, lateral parietal ...