Ovarian cancer cells exploit cell competition by altering Flower protein isoforms in stromal cells, promoting tumor survival ...

With WES, you genetically analyze the section of your DNA that codes proteins. WTS examines all your RNA transcripts to map genes, measure transcripts, analyze splicing, and other key roles. WES is ...

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol Cell ... CHARENTON, C. & NAGAI, K. 2020. RNA Splicing by the Spliceosome. Annu Rev Biochem, 89, 359-388.

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

SB-007 is a protein splicing gene therapy that uses an adeno-associated virus to deliver a full-length ABCA4 gene and aims to restore expression of the ABCA4 protein in the retina. Since the ABCA4 ...

“Precisely identifying splicing sites is key to understanding how cells interpret genetic instructions ... whether it’s turned on or off—in different conditions. “For example, cancer researchers often ...

Transfer RNA-derived fragments (tRFs) are small molecules present in most organisms. tRHs or tRNA halves are generated when certain tRFs are split at specific sites by enzymes. Although ...

Johns Hopkins researchers have developed a powerful new AI tool called "Splam" that can identify where splicing occurs in ...

A novel study from Korea uncovers the process of synthesis and pivotal role of the transfer RNA-derived fragment, ...

Phase 1/2 study initiated for ATX-559, a first-in-class inhibitor of DHX9, focused on patients with BRCA1/2-deficient breast cancer and MSI-H and/or dMMR ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could ...

To fill this knowledge gap, a group of researchers led by Professor Kangseok Lee, from the Department of Life Science, ...