A groundbreaking discovery has highlighted lithium—a drug long used to treat bipolar disorder and depression—as a potential therapy for autism ...

Phosphorylation is the most ubiquitous modification found in cells. Enzymes that catalyze the reaction of transferring phosphate groups to proteins using adenosine triphosphate as a substrate are ...

Post-translational modification generally refers to the addition of a functional group covalently to a protein as in phosphorylation ... predictions of enzyme–substrate interactions suggest ...

Phosphorylation of Phactr1/PP1 substrates IRSp53 S455 and Afadin S1275 is shown below ... Underlining shows sequences N-terminally linked to 6-carboxyfluorescein (FAM) for use in fluorescence ...

Since tumors require substantial energy for growth and glucose is readily available, malignant cells often rely on glucose as their primary source of ATP via substrate-level phosphorylation ...

RESULTS: Our proteomics data identified 188 significantly differentially regulated proteins in response to LacCer treatment, with a significant number of proteins involved in glycolysis, oxidative ...

Early technologies to globally map phosphorylation were aimed at identifying novel kinase–substrate relationships. These technologies took the strategy of increasing the throughput of in vitro ...

Thus, strains containing the mutated kinase or substrate alone were viable ... to develop new technology aimed at globally mapping phosphorylation in eukaryotes. A number of technologies have ...