Chronic nitric oxide (NO) donor treatment is a novel antiepileptic strategy that has an effect beyond neuronal ion channels.

This is not adequately addressed. The authors did not test whether an apparent "kindling" effect, apparently seen in naïve controls, also occurred in animals micro-injected with kainic acid (KA). This ...

Background: The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementation demonstrated a significant ...