Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

The subsequent breakdown of the nuclear envelope terminates prophase and initiates prometaphase, during which the chromosomes become attached to and positioned on the mitotic spindle as it forms.

One possible approach for cancer therapy is to develop inhibitors that block the function of key molecules that are required for complete cell division. Steegmaier and colleagues, writing in ...