The role of hepatocytes and oval cells in liver regeneration and ...
Transplantation and repopulation experiments have demonstrated that hepatocytes, which are highly differentiated and long-lived cells, have a remarkable capacity for multiple rounds of replication. In this article, we review some aspects of the regulation of hepatocyte proliferation as well as the interrelationships between hepatocytes and oval ...
Liver, Oval Cell - Hyperplasia - Nonneoplastic Lesion Atlas
2024年6月3日 — Oval cell hyperplasia (Figure 1) is rarely seen in control animals. It typically begins either in periportal areas or in subcapsular regions of the liver. The proliferating oval cells are spindloid and initially extend out from portal areas in a linear array; they may encircle hepatic lobules, and in severe cases they may form irregular solid ...
Liver Injury and Regeneration: Current Understanding, New …
2023年8月22日 — The activation of quiescent hepatocytes that proliferate and restore the liver mass by upregulating genes involved in cell-cycle progression, DNA repair, and mitochondrial function; the proliferation and differentiation of progenitor cells, also known as oval cells, into hepatocytes that contribute to liver regeneration; and the recruitment of ...
肝脏卵圆细胞 - Baishideng Publishing Group
一般认为, 肝脏卵圆细胞直径为10-15 μm, 表达OV-6、细胞角蛋白19、谷氨酰转肽酶、部分表达白蛋白及甲胎球蛋白, 但不表达过氧化物酶 [1], 近年来研究发现, 肝脏卵圆细胞膜表面也表达造血干细胞标志Thy-1 [2] , 并被认为是肝脏祖细胞 [3, 4]. 随着干细胞技术及研究的迅速发展, 肝脏卵圆细胞已成为肝脏病学中的研究热点之一, 本文将近年来的有关研究进行综述. 1 卵圆细胞的来源. 一般认为肝脏卵圆细胞来源于位于hering管的肝脏干细胞 [5 - 7].
Oval Cell - an overview | ScienceDirect Topics
Oval cells are a specific type of cells with oval shaped nucleus that appear in the injured liver when hepatocyte proliferation is inhibited by toxins or genetic changes. It is not clear with regard to the cell origin of oval cells. 2AAF(N-acetylaminofluorene)/PHx inhibits hepatocyte proliferation and induces oval cell activation in a rat model ...
Isolation and Characterization of Hepatic Stem Cells, or “Oval Cells ...
The extensively characterized rat hepatic stem/progenitor cell, or oval cell, has been demonstrated by our laboratory, as well as several others, to show particular promise as a tool for the treatment of genetic liver disorders and as a bridging therapy or alternative to liver transplant (1–4).
Liver progenitor cell-driven liver regeneration | Experimental
2020年8月14日 — On the other hand, when hepatocyte proliferation is compromised, BECs are able to dedifferentiate into liver progenitor cells (LPCs), also known as oval cells.
Liver regeneration: Cellular origin and molecular mechanisms
2022年2月2日 — Following studies characterized oval cells as hyperplastic epithelial cells with small cellular size, a high nuclear/plasma ratio and expression of the hepatoblast marker alpha-fetoprotein (AFP). 8-11 Oval cells were considered to be bipotential progenitor cells as they showed the capacity to differentiate into hepatocytes and bile duct cells ...
Oval cell‐mediated liver regeneration: Role of cytokines and …
2002年12月20日 — These stem cells may give rise to oval cells, which can differentiate into mature hepatocytes. Oval cells are bipotential stem cells, originating from the canals of Hering, which differentiate to produce cells of either the hepatocytes or biliary epithelia lineage.
Signaling networks in hepatic oval cell activation - ScienceDirect
2008年6月1日 — Oval cells are hypothesized to be the progeny of intrahepatic stem cells, also referred to as adult liver stem cells. The mechanisms by which these cells are activated to proliferate and differentiate during liver regeneration is important for the development of new therapies to treat liver disease.