Subretinal Injection Techniques for Retinal Disease: A Review
Subretinal injection has been proposed as a suitable approach for treating these conditions. Accessing the subretinal space (SRS), the potential area between the neurosensory retina and the RPE, allows direct contact of the drug with the PR and RPE layers, optimizing the concentration of the drug in these cells.
Subretinal Injection Techniques for Retinal Disease: A Review
2022年8月12日 · Subretinal injection has been proposed as a suitable approach for treating these conditions. Accessing the subretinal space (SRS), the potential area between the neurosensory retina and the RPE, allows direct contact of the drug with the PR and RPE layers, optimizing the concentration of the drug in these cells.
The Role of Subretinal Injection in Ophthalmic Surgery: …
Subretinal injection is performed in vitreoretinal surgery with two main aims, namely, the subretinal delivery of therapeutic agents and subretinal injection of fluid to induce a controlled and localized macular detachment.
Subretinal Injection: A Review on the Novel Route of Therapeutic ...
2017年9月1日 · Compared to intravitreal injection, subretinal injection has more direct effects on the targeting cells in the subretinal space, which provides a new therapeutic method for vitreoretinal diseases, especially when gene therapy and/or cell therapy is involved.
The Role of Subretinal Injection in Ophthalmic Surgery ... - MDPI
2023年6月23日 · Subretinal injection is a delicate surgical maneuver whose application in vitreoretinal surgery is progressively increasing. This is mainly due to the suitability of subretinal injection to deliver a controlled amount of therapeutic agent directly to the retinal pigment epithelium (RPE) cells and photoreceptors.
An Optimized Treatment Protocol for Subretinal Injections Limits ...
Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to deliver adeno-associated virus (AAV) to photoreceptors and retinal pigment epithelial cells. We present an optimized surgical protocol to minimize off-target application of AAV in the vitreous, which in turn reduces the risk of extensive biodistribution and ...
Subretinal Therapy: Technological Solutions to Surgical and ...
Recent advances in ocular gene and cellular therapy rely on precisely controlled subretinal delivery. Due to its inherent limitations, manual delivery can lead to iatrogenic damage to the retina, the retinal pigment epithelium, favor reflux into the vitreous cavity.
Subretinal Drug Administration - an overview - ScienceDirect
Subretinal administration is mostly used in the sense of gene therapy for targeting the macromolecules in the retinal cells [38]. The subretinal injection offers novel gene therapeutic approaches for vitreoretinal disorders as it has a direct cell targeting effect.
Subretinal injection in mice to study retinal physiology and disease
2022年4月13日 · Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such as...
The Role of Subretinal Injection in Ophthalmic Surgery ... - PubMed
2023年6月23日 · Subretinal injection is performed in vitreoretinal surgery with two main aims, namely, the subretinal delivery of therapeutic agents and subretinal injection of fluid to induce a controlled and localized macular detachment. The growing interest in this technique is mainly related to its suitability …