CD40 Gene - GeneCards | TNR5 Protein | TNR5 Antibody
2024年12月9日 · CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Agammaglobulinemia, X-Linked. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Molecular basis and therapeutic implications of CD40/CD40L …
CD40, also known as Bp50 and TNFRSF5, is a type I membrane glycoprotein with a 62 amino acid (aa) cytoplasmic tail, a 22 aa transmembrane domain and a 173 aa extracellular domain in human. It was first discovered in 1987 as a 50-kDa protein expressed on B cells which regulates B cell proliferation.
CD40 Ligand - an overview | ScienceDirect Topics
CD40 ligand (CD40L) is a 261-amino-acid membrane glycoprotein expressed on activated CD4 lymphocytes. Expression occurs shortly after T cell activation. The natural ligand for CD40L is CD40, which is a transmembrane protein present on …
CD40: Lord of the endothelial cell | Blood - American Society of …
2008年11月1日 · CD40 has a rich history as a prominent immune cell activator. 1 CD40 is best known as the key mediator of B lymphocyte immunoglobulin class switch. It also serves as a major activator of antigen-presenting cells, such as macrophages and dendritic cells.
CD40 stimulation as a molecular adjuvant for cancer vaccines …
2021年7月19日 · In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma. Int. J. Hyperth. 2019;36:64–73.
Molecular basis and therapeutic implications of CD40/CD40L …
2021年3月1日 · CD40, also known as Bp50 and TNFRSF5, is a type I membrane glycoprotein with a 62 amino acid (aa) cytoplasmic tail, a 22 aa transmembrane domain and a 173 aa extracellular domain in human. It was first discovered in 1987 as a 50-kDa protein expressed on B cells which regulates B cell proliferation (Ledbetter, Shu, Gallagher, & Clark, 1987 ...
CD40-CD40 ligand - PubMed
This article reviews recent developments in this field of research, with main emphasis on (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types; and (4) in vivo functions of CD40/CD40-L interactions.
CD40 function in immune development and response: Cell type ...
2019年5月1日 · Initial results indicate that CD40 on thymic epithelial cells and DC contributes to negative selection of tissue restricted antigen-binding T cells. These results identify different CD40-dependent APC requirements and suggest distinct CD40 signaling pathways for specific immune responses.
CD40–CD40L in Neurological Disease - PMC - PubMed Central …
We review the effects of CD40 signaling in traumatic brain injury, Alzheimer’s Disease, Parkinson’s Disease, stroke, epilepsy, nerve injury, multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis, and brain tumors, and highlight recent therapeutic advancements targeting the CD40–CD40L system. 2. CD40–CD40L Molecular Signaling Overview
CD40 is an immune checkpoint regulator that potentiates …
2024年3月14日 · Here, we leveraged genetic mouse models, single cell sequencing, and cell depletion studies to demonstrate that an anti-CD40 agonist antibody reshapes the cardiac immune landscape through activation of CCR2 + macrophages and subsequent recruitment of effector memory CD8 T-cells.
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