The Diagnostic Value of TTF-1, P63, HMWK, CK7, and CD56 …
2017年7月1日 — All adenocarcinomas were positive for CK7 and most of them (18/20; 90%) were positive for TTF-1. Most of small cell lung carcinomas were positive for TTF-1 (17/20; 85%), and CD56 (18/20; 90%). All squamous cell carcinomas (SCCs) were negative for TTF-1, but most of them were positive for HMWK (34βE12) and P63.
Immunohistochemical profiles in primary lung cancers and ... - PubMed
Primary lung squamous cell carcinomas expressed CK5, p40, and p63 in 94%-97% of cases, whereas 44% were positive for CK7, 20% for GATA3, 7% for CDX2, and 3% for TTF-1. Rare cases expressed PAX8, CK20, or napsin A. Pulmonary metastases of colorectal cancer were positive for CK20 in 83% and CDX2 in 99% of the cases.
Best Practices Recommendations for Diagnostic Immunohistochemistry …
2018年12月17日 — Almost all studies have demonstrated high sensitivity of CK7 for diagnosing lung adenocarcinoma, ranging from 92% to 100%, thus contrasting with its low specificity (ranging from 50% to 93%) when compared with other markers such as napsin A and TTF1 . 18,30–39 Indeed, according to a recent series, 5% to 77% (mean 25%) of squamous cell ...
Cytokeratins and lung carcinomas - PubMed
In this study, expression of CK7, CK10/13, CK18, CK19, CK20 was investigated in a group of 72 surgically resected specimens of lung including 31 adenocarcinomas, 30 squamous cell carcinomas and 11 neuroendocrine carcinomas.
An Immunohistochemical Expression of CK5/6, CK7, and CK20 on Cell …
2022年7月26日 — CK5/6 is a high-molecular-weight cytokeratin and expressed in neoplasms of epithelial origin including SCC, mesothelial carcinoma, and urothelial carcinoma. Similarly, CK20 and CK7 have been used successfully in studies determining the primary location of adenocarcinomas.
Cytokeratin 7 and Cytokeratin 20 Expression in Epithelial
2000年9月1日 — Expression of CK 7 was seen in the majority of cases of carcinoma, with the exception of those carcinomas arising from the colon, prostate, kidney, and thymus; carcinoid tumors of the lung...
Immunohistochemistry in the Differential Diagnostics of Primary Lung …
2013年1月7日 — In summary, at our department, CK5 and TTF1 are very sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung, respectively. The addition of NAPA contributes to an even higher sensitivity for adenocarcinomas. CK5 is also highly specific for squamous cell carcinoma.
A panel of four immunohistochemical markers (CK7, CK20, TTF
2013年10月15日 — We evaluated, on a retrospective series of biopsy specimens, the performance of a four-antibody IHC panel for accurate subclassification of non-small cell lung carcinoma (NSCLC) and for identification of metastatic carcinoma. Tumor morphology was assessed and IHC for CK7, CK20, TTF-1, and p63 was performed according to a two-step algorithm.
Utility of five commonly used immunohistochemical markers TTF ... - PubMed
2015年4月21日 — Background: Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell …
A combination of cytokeratin 5/6, p63, p40 and MUC5AC are …
2020年8月26日 — Our study showed that the positive rate of CK7 was 49% in cervical poorly differentiated squamous cell carcinoma, which further suggested that CK7 is not an ideal marker for differentiation between squamous cell carcinoma and adenocarcinoma.