Beyond Poly(ethylene glycol): Linear Polyglycerol as a …
2014年5月9日 · Chemical structures of poly(ethylene glycol) (PEG), linear polyglycerol (linPG) and hyperbranched polyglycerol (hbPG). This review focuses on synthetic procedures, functionalization possibilities and potential applications of lin PG (middle).
Beyond poly(ethylene glycol): linear polyglycerol as a …
2014年6月9日 · This review summarizes the properties and synthetic approaches toward linear polyglycerols (linPG), which are at present mainly based on the application of ethoxyethyl glycidyl ether (EEGE) as an acetal-protected glycidol derivative.
Polyglycerols as Multi-Functional Platforms: Synthesis and ... - MDPI
2022年6月30日 · By chemical protection of the hydroxy group in glycidol, the proton exchange during polymerization can be efficiently hampered to obtain linear structures. In the next step after polymerization, deprotection yields linear polyglycerol (LPG) with free hydroxy groups.
Polyglycerols - ScienceDirect
2018年1月1日 · In this chapter, an overview is provided with respect to synthetic strategies toward linear, hyperbranced, and perfect dendritic polyglycerols, characteristic features that highlight the advantages of PG over PEG, and potential applications of PGs in various smart supramolecular structures such as tailored pH-, thermo-, and light responsive drug...
超越聚乙二醇：线性聚甘油作为生物医学和制药应用的多功能聚 …
2014年5月29日 · 这篇综述总结了线性聚甘油的特性和合成方法（林PG），目前主要基于乙氧基乙基缩水甘油醚（EEGE）作为乙缩醛保护的缩水甘油衍生物的应用。 特别强调多方面的功能化策略，包括例如在聚醚主链上合成末端官能的lin PGs或多官能的修饰。 讨论了潜在的应用，如生物共轭和利用作为可降解生物材料的组成部分或用于诊断，其中聚甘油可作为有前途的PEG替代品。 在最后一部分中，强调了线性聚甘油在嵌段共聚物或三元共聚物中作为大分子引发剂或高度亲水 …
Synthesis of linear polyglycerols with tailored degree of …
2017年7月14日 · We introduce a two-step strategy for the synthesis of linear polyglycerols (lin PG-OH x /OMe y) with an adjustable degree of methylation (y = D M 100).
Linear Polyglycerol for N-terminal-selective Modification of ...
In this article, we synthesized N-terminal bioconjugates of the potential therapeutic human interleukin-4 (hIL-4 WT) with linear polyglycerol (LPG) of 10 and 40 kDa and compared it with its PEG analogs of same nominal weights.
Linear Poly(methyl glycerol) and Linear Polyglycerol as Potent …
2010年7月2日 · A fast and efficient approach to terminal-functionalized linear polyglycerols for subsequent surface modification is described. The resulting biocompatibility of the functionalized surfaces in comparison to a PEG-functionalized surface is demonstrated by protein adsorption and cell-adhesion testing.
Synthesis of linear polyglycerols with tailored degree of …
2017年7月14日 · We introduce a two-step strategy for the synthesis of linear polyglycerols (lin PG-OH x /OMe y) with an adjustable degree of methylation (y = D M 100).
linear polyglycerol structures with pendant glycerol units providing vicinal 1,2-diols after removal of the acetonide protecting group. Typical polymerization procedures and general mechanisms for epoxide polymerization have recently been summarized in an excellent review by Carlotti et al.31