In vivo and in vitro experiments on the effects of praziquantel on ...
The effects of 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide) on Schistosoma mansoni was studied in vivo and in vitro by means of electron microscopy.
Light and electron microscopic studies on the effect of …
The fine structure of the tegument of three trematode species, Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica, was studied by means of light scanning (SEM) and transmission electron microscopy (TEM) after in vitro exposure to 0, 1, 10, and 100 micrograms/ml of the anthelmintic praziquantel for 5, 15, 30, and 60 min.
Light and scanning electron microscopy studies on the effects of …
In the present study, the effects of the enantiomers of the anthelmintic drug praziquantel (PZQ) and its main metabolite trans -4-hydroxypraziquantel (TRANS) on pairs of Schistosoma mansoni worms were examined in vitro. Highly purified enantiomers (optical purity, >99.9% for PZQ and 99.0% for TRANS) were used.
Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica, was studied by means oflight scanning (SEM) and transmission electron micros-copy (TEM) after invitro exposure to0, 1, 10, and 100 gg/ml ofthe anthel-mintic praziquantel for 5,15, 30, and 60 rain.
Pharmacological and immunological effects of praziquantel against
2018年2月7日 · Praziquantel has three unique pharmacological effects on S. japonicum and S. mansoni, i.e., stimulation of worm motor activity, spasmodic contraction of the musculature, and vesicle formation in tegument [20, 21, 22, 23, 24, 25]. The former two actions link the subsequent hepatic shift of the worms in vivo, while the latter is key to kill the worm.
The effect of praziquantel on Schistosoma mansoni - PubMed
3 x 10 (-6)M praziquantel fails to completely paralyse miracidia and cercariae in a short time but they are not infective when maintained in the solution. 3 x 10 (-5)M praziquantel prevents infected snails shedding cercariae but does not kill daughter sporocyts or developing cercariae.
The effect of Praziquantel on Schistosoma mansoni
2009年6月5日 · As the action of praziquantel on adult worms is not blocked by 10 −2 M mecamylamine, pempidine or carbachol, but is reduced by calcium deplection, it is suggested that praziquantel may act by permitting calcium influx to muscle cells causing them to contract. Get access to the full version of this content by using one of the access options below.
Human antibody responses to Schistosoma mansoni: the influence …
Since antigens have been identified in S. mansoni eggs [8, 91 and adult worms [2] which share epitopes with the schistosomular surface, it would seem likely that the persistent exposure to antigenic material released from parasite eggs and adult worms might have both a qualitative and quantitative influence on the nature of the immunological re...
(PDF) Schistosoma mansoni: Complexity of antigenic and …
The recognition of Schistosoma mnnsoni surface antigen by anti- REFERENCES bodies from patients infected with S. mansoni and S. haematobium. Transactions of the Royal Society CROSS,G. A. M. 1975. Identification, purification and of Tropical Medicine and Hygiene, in press.
Light and electron microscopic studies on the effect of …
The fine structure of the tegument of three trematode species, Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica, was studied by means of light scanning (SEM) and transmission electron microscopy (TEM) after in vitro exposure to 0, 1,10, and 100 μg/ml of the anthelmintic praziquantel for 5, 15, 30, and 60 min.